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The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation.

Observational, multi-center, non-randomized, post-market study. This is a nested sub-study of the REAL AF Registry. Consecutive symptomatic drug refractory paroxysmal atrial fibrillation (PAF) patients from the registry will be screened for enrollment, prospectively or retrospectively, to this sub-study per inclusion and exclusion criteria.

18 years of age All Phase N/A
F François-Daniel ARDELLIER, MD

Comparison of Diagnostic Performances of 3D FLAIR, DIR and PSIR Sequences in Optic Neuritis

Ultimately improve the care of patients suffering from multiple sclerosis (1st cause of acquired non-traumatic disability in adults) and NMO spectrum diseases by using more efficient MRI sequences than the FLAIR sequence commonly used in detection of optic neuritis. In the literature, many studies have already focused on comparing the …

18 years of age All Phase N/A
G Georges-Emmanuel ROTH, Midwife

Quantitative Assessment of Signal Loss in Cardiotocography Using External Recording

Signal loss in cardiotocography (CTG) recordings is numerous and frequent, whether due to artifacts in signal acquisition or confusion over inadvertent maternal heart rate recording, with various negative consequences for neonatal morbidity and unnecessary obstetric interventions. Data on this issue are 10 to 15 years old. CTG remains the primary …

18 - 45 years of age Female Phase N/A
F Fernando MP Santos

Biomarkers in Inflammatory Rheumatic Diseases Diagnosis

Ankylosing spondylitis (AS), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are three diseases where early diagnosis remains a major challenge. However, early diagnosis is the main determinant for a better prognosis. In the early stage, symptoms may be nonspecific and often difficult to establish a differential diagnosis between rheumatic …

18 - 65 years of age All Phase N/A
A Andrea Bruni

Analysis of the Pulmonary Microbiome

The purpose of the protocol is to study the pulmonary microbiome in patients who develop pneumonia.

18 years of age All Phase N/A
F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

A Natural History Study of RYR1-Related Disorders

Background Congenital myopathies (CM) are genetic disorders that can cause decreased muscle tone and muscle weakness. Most CMs in the United States are related to the ryanodine receptor 1 (RYR1) gene. Researchers need more natural history data to learn about these CMs in children and adults. Objective To learn more …

7 - 100 years of age All Phase N/A
L Lynn Thomson

Monitoring Key Activity and Physiology of Neonates in Intensive Care

To optimise and evaluate a novel non-contact physiological monitoring system in the neonatal intensive care unit (NICU)

years of age All Phase N/A
N Nizar Amllah, M.D

Analysis of Biological Progression and Regression of HELLP Syndrome in Time

Prospective observational study about progression and regression of biological parameters of HELLP syndrome

years of age Female Phase N/A
L Liisa Hantsoo, Ph.D.

Identification and Validation of Epigenetic Biomarkers of PMDD

This research is being done to examine epigenetic markers and mood changes across the menstrual cycle, particularly in premenstrual dysphoric disorder (PMDD). The investigators previously identified epigenetic biomarkers of postpartum depression, another reproductive affective disorder, and in this study aim to determine if these biomarkers also distinguish PMDD cases from …

18 - 50 years of age Female Phase N/A
S Si-Hua Wu, MD

Telpegfilgrastim Injection to Reduce the Risk of Neutropenia in Patients With Solid Tumor

The objective of this real world study is to confirm the efficacy and saftey of Telpegfilgrastim injection for the prevention of chemotherapy-induced Neutropenia in Patients With Malignant solid tumor.

18 - 70 years of age All Phase N/A

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